Chimeric Antigen Receptor on T Cell (CAR-T)

Chimeric antigen receptors (CARs) are engineered receptor proteins that endow T cells with the ability to recognize and attack specific antigens, typically found on cancer cells. CAR-T cell therapy involves collecting a patient's own T cells, genetically modifying them in the laboratory to express a CAR targeting a tumor-associated antigen, and then infusing these modified cells back into the patient to fight cancer.

Other names

CARChimeric Antigen Receptor T-cellCAR modified T cell

MHC-independent binding to target antigen, activation of T cell signaling pathways, release of cytolytic molecules, cytokine secretion, and induction of apoptosis in target cells.