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Chitin Synthase (None)
- Target
- None
- Molecular classification
- Enzyme, Glycosyltransferase family GT2
01
Overview
Chitin synthase is a membrane-bound glycosyltransferase enzyme responsible for the biosynthesis of chitin, a linear polymer composed of β-(1,4)-linked N-acetylglucosamine (GlcNAc) units. Chitin is a major structural component in fungal cell walls and insect exoskeletons. The enzyme catalyzes the transfer of GlcNAc from UDP-GlcNAc to the non-reducing end of a growing chitin chain, forming β(1→4) glycosidic linkages and simultaneously transporting the nascent polymer through the plasma membrane. It is a validated target for antifungal and insecticide drugs.
02
Mechanism of action
Inhibition of chitin synthesis
03
Biological functions
Chitin synthesisCell wall biosynthesisExoskeleton formationCell divisionMorphogenesisEnvironmental resistance
04
Disease associations
Infection
05
Interacting drugs
Peptidyl nucleosides
1 more in the full profile.
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