Chitin Synthase (None)

Chitin Synthase Overview

Chitin synthase is a membrane-bound glycosyltransferase enzyme responsible for the biosynthesis of chitin, a linear polymer composed of β-(1,4)-linked N-acetylglucosamine (GlcNAc) units. Chitin is a major structural component in fungal cell walls and insect exoskeletons. The enzyme catalyzes the transfer of GlcNAc from UDP-GlcNAc to the non-reducing end of a growing chitin chain, forming β(1→4) glycosidic linkages and simultaneously transporting the nascent polymer through the plasma membrane. It is a validated target for antifungal and insecticide drugs.

Mechanism of Action

Inhibition of chitin synthesis

Biological Functions

Safety Considerations

Interacting Drugs