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Chitinase (Family 18)

Molecular classification: Enzyme, Glycoside Hydrolase Family 18 (GH18)

Overview

Chitinases from glycoside hydrolase family 18 (GH18) are enzymes that catalyze the hydrolysis of chitin, a linear polymer of N-acetyl-β-D-glucosamine. GH18 chitinases are widely distributed and play diverse biological roles such as nutrient acquisition, morphogenesis, defense against pathogens, and involvement in immune responses including allergic inflammation.

Mechanism of action

Hydrolyzes β-1,4-glycosidic bonds in chitin; inhibition of chitinase activity

Biological functions

Nutrient acquisitionMorphogenesis (e.g., ecdysis)Defense against pathogens (antifungal)Immune response modulationCell wall remodeling/growth

Disease associations

InflammationAllergyInfection

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