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Chitinase domain-containing protein 1 (CHID1)
- Target
- CHID1
- Molecular classification
- Other (Chitinase-like protein, Glycosyl hydrolase 18 family; it lacks confirmed enzymatic chitinase activity)
01
Overview
Chitinase domain-containing protein 1 (CHID1) is a highly conserved, ubiquitously expressed protein found on human chromosome 11 (p15.5), containing a chitinase-like domain but lacking confirmed enzymatic activity. It is part of the Glycosyl hydrolase 18 family, with evolutionary conservation across species from primates to insects. The protein binds carbohydrates and possibly lipopolysaccharides (LPS), showing preference for chitotetraose in vitro. Its biological functions remain speculative, with proposed roles in carbohydrate metabolism, immune signaling, and pathogen sensing, likely mediated in part by interaction with stabilin-1. Despite wide tissue expression, there is currently no evidence of CHID1 involvement in known diseases or as a therapeutic target, and no drugs or biomarkers are identified for it
- Other names
- CHID1SI-CLPSICLPGL008PSEC0104SB139MGC3234FLJ42707Stabilin-1-interacting chitinase-like proteinstabilin-1 interacting chitinase-like proteinchitinase domain-containing protein 1
02
Mechanism of action
No mechanism of action for drugs is available, as it is not a drug target
03
Biological functions
Carbohydrate bindingOligosaccharide binding activityPossible roles in chitin catabolism or carbohydrate metabolismNegative regulation of cytokine production involved in inflammatory responsePossible involvement in pathogen sensing and endotoxin neutralization
04
Disease associations
No clear disease association or established role in specific pathologies such as cancer, inflammation, neurodegenerative disease, etc. As of now, CHID1 has not been directly linked to major human diseases
05
Safety considerations
No safety profile or therapeutic challenges are recognized, as it is not actively targeted in therapy
06
Interacting drugs
No chemically validated drugs are reported to interact with CHID1
07
Biomarkers
CHID1 is not used as a clinical biomarker for patient selection or disease monitoring
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