Molecular Classification
Enzyme, Transferase, Acyltransferase
Other Names
CAT Enzyme, Chloramphenicol Transacetylase, Chloramphenicol O-Acetyltransferase
Disease Roles
Antibiotic resistanceInfection

Chloramphenicol Acetyltransferase Overview

Chloramphenicol acetyltransferase (CAT) is a bacterial enzyme (EC 2.3.1.28) that confers antibiotic resistance by catalyzing the acetylation of chloramphenicol, thus preventing its binding to bacterial ribosomes and inhibiting protein synthesis. CAT exists as a trimer and its activity inactivates chloramphenicol, thiamphenicol, and azidamfenicol.

Mechanism of Action

Acetylation of chloramphenicol, preventing ribosome binding

Biological Functions

Antibiotic resistance
Detoxification

Disease Associations

Antibiotic resistance
Infection

Safety Considerations

  • Antimicrobial resistance
  • Potential adverse effects

Interacting Drugs

Chloramphenicol
Thiamphenicol
Azidamfenicol
Fusidic acid
Streptogramin