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Target intelligence / Profile preview
Chloramphenicol Acetyltransferase (CAT)
- Target
- CAT
- Molecular classification
- Enzyme, Transferase, Acyltransferase
01
Overview
Chloramphenicol acetyltransferase (CAT) is a bacterial enzyme (EC 2.3.1.28) that confers antibiotic resistance by catalyzing the acetylation of chloramphenicol, thus preventing its binding to bacterial ribosomes and inhibiting protein synthesis. CAT exists as a trimer and its activity inactivates chloramphenicol, thiamphenicol, and azidamfenicol.
- Other names
- CAT EnzymeChloramphenicol TransacetylaseChloramphenicol O-Acetyltransferase
02
Mechanism of action
Acetylation of chloramphenicol, preventing ribosome binding
03
Biological functions
Antibiotic resistanceDetoxification
04
Disease associations
Antibiotic resistanceInfection
05
Safety considerations
Antimicrobial resistancePotential adverse effects
06
Interacting drugs
Chloramphenicol
4 more in the full profile.
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