Chloride channel accessory 3 pseudogene (CLCA3P)

Chloride channel accessory 3 pseudogene (CLCA3P) is a transcribed pseudogene belonging to the calcium-sensitive chloride conductance protein family[3][4][8]. In humans, the transcript contains several nonsense codons, making it subject to nonsense-mediated mRNA decay and it is not believed to encode a functional protein[1][3][8]. While proteins in this family can be functional in other species (such as mice), and CLCA3 homologues participate in the regulation of chloride ion transport and may contribute to mucus secretion in goblet cells, the human CLCA3P is likely a non-functional processed pseudogene and not considered a therapeutic target in humans[1][2][3][4]. Most references indicate that it does not produce a protein in humans, though some older or less-confirmed reports suggest the possibility of expression, but this remains unverified[1][2]. As such, the gene has no established drug interactions, mechanisms of action, biomarker roles, or relevance for safety assessment in drug development.

Other names

CLCA3chloride channel accessory 3chloride channel, calcium activated, family member 3chloride channel regulator 3 pseudogene