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Target intelligence / Profile preview
Chloride Channel Protein (ClC)
- Target
- ClC
- Molecular classification
- Ion channel, Transporter (some CLC members)
01
Overview
Chloride channel proteins are integral membrane proteins that facilitate the passive movement of chloride ions (Cl⁻) across cellular membranes. They play essential roles in maintaining cell volume, electrical excitability, pH regulation, and transepithelial transport in a wide variety of tissues. The most well-studied family is the CLC (chloride channel) family, which includes both true channels and Cl⁻/H⁺ antiporters. Mutations or dysfunctions in chloride channels are linked to various diseases.
- Other names
- Chloride channelCl- channel
02
Mechanism of action
Inhibition of chloride ion transport
03
Biological functions
Regulation of membrane potentialElectrical excitabilityCell volume regulationIntracellular pH controlTransepithelial transport
04
Disease associations
Myotonia congenitaCystic fibrosisBartter syndromeDent's diseaseEpilepsyOsteopetrosis
05
Safety considerations
Potential for off-target effects due to structural similarities between subtypesDysregulation can lead to a variety of diseases
06
Interacting drugs
9-anthracene carboxylic acid
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