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Chloride channel protein 1 (ClC-1)

Target: ClC-1
Molecular classification: Ion channel, Voltage-gated chloride channel

Overview

Chloride channel protein 1 (ClC-1) is a voltage-gated chloride channel primarily expressed in skeletal muscle. It plays a crucial role in maintaining the resting membrane potential and regulating muscle excitability. ClC-1 forms a homodimeric structure, with each subunit containing its own ion-conducting pore. Mutations in the CLCN1 gene, encoding ClC-1, lead to myotonia congenita, a condition characterized by delayed muscle relaxation. The channel's function is essential for proper muscle contraction and relaxation cycles.

Other names: CLCN1

Mechanism of action

Modulation of chloride ion conductance through the channel

Biological functions

Chloride ion transportRegulation of muscle excitabilityMaintenance of resting membrane potential in skeletal muscle

Disease associations

Myotonia congenita

Safety considerations

Potential for off-target effects on other chloride channels.

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