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Target intelligence / Profile preview
Chloride channel protein 7 (CLCN7)
- Target
- CLCN7
- Molecular classification
- Voltage-gated chloride/proton exchanger, CLC family, Transporter
01
Overview
Chloride channel protein 7 (CLCN7) is a chloride/proton antiporter primarily located in lysosomes and late endosomes. It plays a crucial role in maintaining lysosomal acidification and bone remodeling. Mutations in CLCN7 are associated with autosomal dominant osteopetrosis type II and potentially other lysosomal storage or neurodegenerative diseases. ClC-7 functions as a homodimer, exchanging two chloride ions for one proton. It's essential for osteoclast function by regulating the acidity required for bone resorption.
- Other names
- ClC-7
02
Biological functions
Lysosomal acidificationEndosomal acidificationBone resorptionChloride transportProton transportpH regulationIon homeostasis
03
Disease associations
Osteopetrosis type IILysosomal storage diseasesNeurodegenerative diseases
04
Safety considerations
Potential for disrupting lysosomal function leading to cellular dysfunctionOff-target effects on other CLC family members
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