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Target intelligence / Profile preview
Chloride Channel Protein Anoctamin 1 (ANO1)
- Target
- ANO1
- Molecular classification
- Ion channel, Calcium-activated chloride channel (CaCC)
01
Overview
ANO1 is a calcium-activated chloride channel (CaCC) involved in a wide array of physiological processes including transepithelial anion transport, smooth muscle contraction, and pacemaking activity in the gastrointestinal tract. It functions as a dimer, with each subunit containing ten transmembrane domains. ANO1's role in various diseases, particularly cancer, makes it an emerging drug target, although challenges remain regarding selectivity and potential off-target effects.
- Other names
- TMEM16ATransmembrane member 16A
02
Mechanism of action
Pharmacological antagonism (channel blockade)
03
Biological functions
Anion transport (Cl⁻ > HCO₃⁻ > I⁻)Smooth muscle contractionPacemakingTransepithelial anion transportFluid/electrolyte secretionCardiac excitabilityNeuronal signalingVascular tone regulationHeat pain sensation
04
Disease associations
CancerHypertensionGastrointestinal motility disordersCystic fibrosis
05
Safety considerations
Selectivity challenges due to similarities among related channelsPotential effects on physiological processes beyond oncology (e.g., myometrial relaxation)
06
Interacting drugs
ANO1 inhibitors (small-molecule inhibitors)
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