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Target intelligence / Profile preview
Chloride Channel Protein CIC-2 (CLCN2)
- Target
- CLCN2
- Molecular classification
- Ion channel, Voltage-gated chloride channel
01
Overview
Chloride channel protein CIC-2, encoded by the CLCN2 gene, is a voltage-gated chloride channel. It plays a crucial role in maintaining chloride ion homeostasis across cell membranes and is involved in various physiological processes including electrical excitability, cell volume regulation, and transepithelial transport. Mutations or dysregulation are associated with neurological disorders like epilepsy and megalencephalic leukoencephalopathy with subcortical cysts.
- Other names
- CLC-2Chloride channel 2
02
Mechanism of action
Currently no highly specific pharmacological modulators for clinical use; research continues into targeting these channels therapeutically for neurological diseases involving altered chloride homeostasis.
03
Biological functions
Chloride ion homeostasisCell volume regulationNeuronal inhibitionMyelin formationRegulation of electrical excitabilityTransepithelial transport
04
Disease associations
EpilepsyMegalencephalic leukoencephalopathy with subcortical cysts (MLC)Neurodegeneration
05
Safety considerations
Altered chloride homeostasis can lead to neuronal hyperexcitability and seizures.Lack of highly specific pharmacological modulators limits therapeutic options.
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