Target intelligence / Profile preview

Chloride channel protein ClC-2 (ClC-2)

Target: ClC-2
Molecular classification: Ion channel, Chloride channel, Voltage-gated ion channel

Overview

Chloride channel protein ClC-2 is a voltage-gated chloride ion channel encoded by the CLCN2 gene. It is a member of the CLC family of chloride channels and transporters, which are involved in the regulation of membrane potential, cell volume, and transepithelial transport. Mutations or dysfunctions in ClC–2 have been linked to several human diseases, including epilepsy and megalencephalic leukoencephalopathy with subcortical cysts.

Mechanism of action

N/A

Biological functions

Regulation of neuronal chloride homeostasisModulation of cellular excitabilityCell volume regulationMaintenance of epithelial transport processes

Disease associations

EpilepsyMegalencephalic leukoencephalopathy with subcortical cystsLeukodystrophy

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