Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Chloride channel protein ClC-Ka (ClC-Ka)
- Target
- ClC-Ka
- Molecular classification
- Ion channel, CLC family of voltage-gated chloride channels
01
Overview
Chloride channel protein ClC-Ka (CLCNKA) is a voltage-gated chloride channel primarily expressed in the kidneys and inner ear. In the kidneys, it mediates transepithelial chloride transport, crucial for salt reabsorption, fluid balance, and blood pressure regulation. In the inner ear, it contributes to potassium recycling essential for hearing function. It requires the barttin beta subunit for functional expression. Variants may be associated with salt-sensitive hypertension.
- Other names
- Chloride channel KaChloride channel protein ClC-KaChloride channel, kidney, AClC-K1CLCK1CLCKA_HUMANhClC-Ka
02
Mechanism of action
Voltage-gated chloride channel activity
03
Biological functions
Chloride transportSalt reabsorptionFluid balance regulationBlood pressure regulationUrinary concentrating mechanismCell volume maintenanceMembrane potential stabilizationSignal transductionPotassium recycling
04
Disease associations
Salt-sensitive hypertension
Beyond the preview
Go deeper on Chloride channel protein ClC-Ka (ClC-Ka).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Chloride channel protein ClC-Ka (ClC-Ka).