Chloride Channels (None)

Chloride channels are a diverse group of anion-selective ion channels that facilitate the passive movement of chloride ions (Cl⁻) and, in some cases, other anions across cellular membranes. They play essential roles in regulating neuronal excitability, muscle contraction (skeletal, cardiac, and smooth), cell volume homeostasis, transepithelial salt transport, and acidification of intracellular organelles. Dysfunction or mutation in specific chloride channel genes leads to diseases such as myotonia congenita (ClC‐1 mutations) or cystic fibrosis (CFTR mutations). These proteins are targets for drug development aimed at modulating their activity—either enhancing function where deficient or inhibiting overactive pathways.

Enhancing function where deficient or inhibiting overactive pathways.