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Chlorogenic Acid
- Molecular classification
- Polyphenol, Ester, Secondary Metabolite
01
Overview
Chlorogenic acid (CGA) is a naturally occurring polyphenolic compound, specifically an ester formed between caffeic acid and quinic acid. It exhibits a wide range of biological activities, including anti-inflammatory, antioxidant, metabolic regulation, and neuroprotective effects. It is found in various plant sources such as green coffee beans, honeysuckle, and potatoes. CGA has potential therapeutic applications against chronic metabolic diseases, neurodegenerative disorders, and skin diseases.
- Other names
- CGA(1S,3R,4R,5R)-3-[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy-1,4,5-trihydroxycyclohexane-1-carboxylic acidCryptochlorogenic acidNeochlorogenic acid
02
Mechanism of action
Inhibition of NF-kB pathways, activation of Nrf2 pathway, activation of AMPK pathways, modulation of neuroreceptors and ion channels.
03
Biological functions
AntioxidantAnti-inflammatoryMetabolic regulationNeuroprotectionAnti-bacterialAnti-tumorLiver protectionKidney protectionCardiovascular health support
04
Disease associations
Chronic metabolic diseasesDiabetesNeurodegenerative disordersSkin diseases
05
Safety considerations
Heat and light sensitivity requires careful extraction and storage (low temperature, dark conditions).
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