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CHN2 antisense RNA 1 (CHN2-AS1) is an antisense long non-coding RNA gene that is transcribed from the genomic region opposite to the CHN2 (chimerin 2) gene. Antisense lncRNAs can regulate the expression of their "sense" protein-coding genes by binding to complementary RNA sequences, influencing mRNA transcription, stability, or translation, and sometimes by recruiting chromatin modifiers or affecting epigenetic marks[7][8][5][1]. While antisense lncRNAs as a class are increasingly recognized for their roles in gene expression and some have been implicated as therapeutic targets or biomarkers in cancer and other diseases[8][3], there is currently no evidence in scientific literature that CHN2-AS1 itself is a validated therapeutic target, disease biomarker, or interacts with any known drugs[1].
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