CHODL antisense RNA 2 (CHODL-AS2)

CHODL antisense RNA 2 (CHODL-AS2) is a long non-coding RNA transcribed in the antisense direction relative to the CHODL (chondrolectin) gene locus. As a natural antisense transcript, CHODL-AS2 may regulate the expression of the CHODL gene or other genomic elements via mechanisms such as transcriptional interference, RNA duplex formation, or modulation of chromatin state[1][2]. Antisense RNAs like CHODL-AS2 are generally involved in fine-tuning gene expression, but functional characterization for this specific transcript is lacking, and no experimentally demonstrated role in disease or well-known signaling pathways has been reported in the literature to date[1][2][3].

Antisense-mediated regulation of neighboring (sense) gene expression through base pairing with target mRNA, influencing transcription, RNA stability, or translation