Cholecystokinin A receptor (CCKAR)

The cholecystokinin A receptor (CCKAR), also known as CCK1 or CCK1R, is a G protein-coupled receptor (GPCR) that primarily binds sulfated members of the cholecystokinin (CCK) family of peptide hormones. It plays a central role in mediating physiological responses to CCK, especially in the gastrointestinal tract and select regions of the central nervous system.

Other names

CCK1Type I cholecystokinin receptorCCK1R

Agonist binding leads to activation of Gq proteins, increasing intracellular calcium via IP₃-sensitive stores. At high agonist concentrations, coupling with Gs proteins can occur, increasing cAMP levels. Coupling with G13 has also been observed, activating RhoA pathways.