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Target intelligence / Profile preview
Cholecystokinin B Receptor (CCKBR)
- Target
- CCKBR
- Molecular classification
- G protein-coupled receptor, Receptor
01
Overview
The cholecystokinin B receptor (CCKBR) is a G protein-coupled receptor that binds cholecystokinin (CCK) and gastrin. It is primarily found in the central nervous system and gastrointestinal tract. Upon ligand binding, the receptor couples to G proteins, mainly Gq/G11, activating phospholipase C signaling pathways. It plays a role in anxiety, feeding behavior, memory, nociception, gastric acid secretion, and dopamine activity. Altered expression is seen in some cancers and polymorphisms are linked to anxiety and hallucinations.
- Other names
- CCK-BRCCK2-RCholecystokinin‑2 ReceptorGastrin receptor
02
Mechanism of action
Agonists activate the receptor leading to G protein activation, mainly Gq/G11, which activate phospholipase C signaling pathways leading to intracellular calcium mobilization. Antagonists block the receptor preventing activation by endogenous ligands.
03
Biological functions
Signal transductionRegulation of gastric acid secretionModulation of anxietyModulation of feeding behaviorModulation of memoryModulation of nociception/pain perceptionModulation of dopamine activity
04
Disease associations
CancerAnxiety disordersParkinson's DiseaseAddictionNeuropsychiatric conditions
05
Safety considerations
Potential impact on drug responses related to addictionPotential impact on drug responses related to neuropsychiatric conditions
06
Interacting drugs
Gastrin I
5 more in the full profile.
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