Target intelligence / Profile preview

Cholecystokinin Receptor (CCK Receptor)

Target: CCK Receptor
Molecular classification: G protein-coupled receptor, Receptor

Overview

Cholecystokinin receptors (CCK receptors) are a family of G-protein coupled receptors (GPCRs) that mediate the physiological effects of the peptide hormones cholecystokinin (CCK) and gastrin. There are two main subtypes: CCK A receptor (CCKAR/CCK1R) and CCK B receptor (CCKBR/CCK2R). They play roles in digestion, behavior, and appetite control.

Other names: CCK1RCCKARCCK A receptorCCK2RCCKBRCCK B receptor

Mechanism of action

Agonists bind to the receptor, activating Gq proteins, leading to phospholipase-C stimulation and increased intracellular calcium. Antagonists block the receptor, preventing activation by endogenous ligands.

Biological functions

Signal transductionPancreatic enzyme secretionGallbladder contractionGastric motilitySatiety signalingAnxiety modulationNociception regulationMemory processesGastric acid secretionMucosal cell growth

Disease associations

Gastrointestinal disordersAnxietyUlcers

Safety considerations

The broad distribution of CCK receptors means that antagonists may have complex effects.Further research is needed to fully elucidate the therapeutic potential and safety profile of CCK receptor modulators.

Interacting drugs

Proglumide

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