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Target intelligence / Profile preview
Cholecystokinin Receptor Type A (CCKAR)
- Target
- CCKAR
- Molecular classification
- G protein-coupled receptor
01
Overview
Cholecystokinin receptor type A (CCKAR), also known as CCK1 receptor, is a G-protein coupled receptor that plays crucial roles in both the gastrointestinal system and the central nervous system. This receptor has been extensively studied for its physiological functions and potential as a drug target. CCKAR primarily signals through the Gq protein pathway and is predominantly expressed in the gastrointestinal tract. It is a major physiological mediator of various digestive functions. In the nervous system, CCKAR regulates satiety and feeding behavior. CCKAR has been implicated in various physiological and pathological conditions, including regulation of appetite and satiety, anxiety regulation, and pain perception.
- Other names
- CCK1 receptorCCK1R
02
Mechanism of action
Gq protein pathway activation leading to increased intracellular calcium levels
03
Biological functions
Pancreatic enzyme secretionPancreatic growthSmooth muscle contraction of the gallbladder and stomachBicarbonate secretionGallbladder emptyingInhibition of gut motilityGastric acid secretionPancreatic juice secretionDigestionSatietyFeeding behaviorBeta-endorphin releaseDopamine releaseDopamine-mediated behaviorTemperature homeostasisInsulin secretionHormone secretion regulationSomatostatin secretion (positive regulation)Calcium ion transport regulationPotassium ion transport regulationResponse to glucocorticoidsResponse to heatResponse to lipopolysaccharideResponse to nutrientsResponse to peptidesResponse to radiationResponse to starvationSignal transduction
04
Disease associations
ObesityAnxiety disordersPain perceptionPancreas developmentOrgan regenerationForebrain developmentNeuron migration
05
Interacting drugs
Cholecystokinin
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