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Target intelligence / Profile preview
Cholecystokinin type 1 receptor (CCK‑1R)
- Target
- CCK‑1R
- Molecular classification
- G protein-coupled receptor, GPCR, Receptor
01
Overview
The cholecystokinin type 1 receptor (CCK‑1R), also known as CCKAR or the cholecystokinin A receptor, is a G protein-coupled receptor (GPCR) that binds sulfated members of the cholecystokinin (CCK) family of peptide hormones. It is primarily involved in mediating physiological responses to CCK, especially in the gastrointestinal tract and nervous system. It plays a role in gallbladder contraction, pancreatic exocrine secretion, gastric acid secretion, gastric emptying, and satiety.
- Other names
- CCKARCholecystokinin A receptor
02
Mechanism of action
Agonist or antagonist binding to CCK-1R modulates downstream signaling pathways involving G proteins, phospholipases, protein kinases, and intracellular calcium levels, ultimately affecting gastrointestinal functions and appetite regulation.
03
Biological functions
Signal transductionRegulation of gallbladder contractionRegulation of pancreatic exocrine secretionRegulation of gastric acid secretionRegulation of gastric emptyingRegulation of satietyAppetite suppressionModulates release of beta‐endorphinModulates release of dopamine
04
Disease associations
ObesityMetabolic syndrome
05
Safety considerations
Limited clinical use of ligands targeting this receptor.Therapeutic challenges in developing selective partial agonists/allosteric modulators.
06
Interacting drugs
Cholecystokinin peptides (e.g., CCK‐8)
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