Target intelligence / Profile preview

Cholera Toxin B Subunit (CTB)

Target: CTB
Molecular classification: Toxin subunit, AB5 toxin family

Overview

Cholera toxin B subunit (CTB) is a non-toxic component of the cholera toxin produced by *Vibrio cholerae*. It forms a homopentameric structure and binds to GM1 gangliosides on cell membranes, facilitating the delivery of the toxic A subunit into target cells. CTB is widely used as a research tool for neuronal tracing, lipid raft marking, and as a vaccine adjuvant due to its immunogenic properties.

Other names: Choleragenoid

Mechanism of action

Binds to GM1 gangliosides to facilitate entry of the cholera toxin A subunit into cells.

Biological functions

Receptor bindingCellular entry facilitationImmunomodulationNeuronal tracing

Disease associations

InfectionVaccine component

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