Cholesin (CHLSN)

Cholesin is a hormone produced by the intestine in response to dietary cholesterol absorption. Its main function is to inhibit cholesterol synthesis in the liver, helping maintain cholesterol homeostasis[3][4][5]. Cholesin exerts its effect by binding to the GPR146 receptor, serving as a key regulator of plasma cholesterol in mammals. The hormone is a product of the *CHLSN* gene (also known as C7orf50). Cholesin’s activity includes suppressing VLDL secretion from hepatocytes, and its expression is upregulated during high-cholesterol diets. As a newly described molecule, it is considered a promising therapeutic target for atherosclerosis and hypercholesterolemia, and it may serve as a biomarker for cholesterol absorption and homeostasis[3][4][5]. If more granular molecular descriptors (sequence, structure, motifs) are needed, C7orf50 encodes a small (22 kDa), basic (pI 9.7) peptide with conserved but largely uncharacterized functional domains, mainly localized to the nucleus and extracellular space[1][4]. There is no evidence of misspelling or incorrect identity; the nomenclature matches the latest literature and databases. Its main role is as a hormone, not a traditional receptor or enzyme; it acts upon a target receptor (GPR146). Current knowledge is limited, but valid and scientifically grounded.

Other names

C7orf50CHLSNMGC11257YCR016WFP15621protein cholesinuncharacterized protein C7orf50

Cholesin binds to GPR146 on hepatic cells, leading to inhibition of cholesterol synthesis and decreased VLDL (very low-density lipoprotein) secretion, reducing circulating cholesterol levels[3][4].