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Target intelligence / Profile preview
Cholesterol 24-hydroxylase (CH24H)
- Target
- CH24H
- Molecular classification
- Enzyme, Cytochrome P450
01
Overview
Cholesterol 24-hydroxylase (CH24H / CYP46A1) is a cytochrome P450 enzyme primarily expressed in the brain, where it plays a crucial role in cholesterol homeostasis. It catalyzes the hydroxylation of cholesterol to 24S-hydroxycholesterol, facilitating cholesterol export from the brain. 24S-hydroxycholesterol also acts as an LXR agonist, influencing lipid metabolism. CH24H is a therapeutic target for neurological disorders, with inhibitors like Soticlestat being developed.
- Other names
- CYP46A1
02
Mechanism of action
Inhibition of cholesterol 24-hydroxylation
03
Biological functions
Cholesterol metabolismSteroid metabolismRegulation of lipid metabolismXenobiotic metabolism
04
Disease associations
Neurodegenerative diseaseEpilepsy
05
Interacting drugs
Soticlestat
2 more in the full profile.
06
Biomarkers
24S-hydroxycholesterol levels in plasma or CSF
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