Target intelligence / Profile preview

Cholesterol 7 alpha-hydroxylase (None)

Target: None
Molecular classification: Enzyme, Cytochrome P450

Overview

Cholesterol 7 alpha-hydroxylase (CYP7A1) is a cytochrome P450 heme enzyme that catalyzes the first and rate-limiting step in the classic pathway of bile acid synthesis from cholesterol. It is essential for cholesterol catabolism, bile acid production, and overall cholesterol homeostasis. Mutations or dysregulation of CYP7A1 are associated with hyperlipidemia, gallstone disease, and resistance to statin therapy. It's also a potential therapeutic target for various metabolic and liver diseases.

Mechanism of action

Inhibition of CYP7A1 leads to reduced bile acid synthesis and increased cholesterol levels. Activation leads to increased bile acid synthesis.

Biological functions

Cholesterol catabolismBile acid synthesisRegulation of cholesterol homeostasis

Disease associations

HyperlipidemiaGallstone diseaseCardiovascular diseaseMetabolic diseaseNAFLD/NASHDiabetesObesityCirrhosisHepatocellular carcinoma

Safety considerations

Drug-drug interactions due to CYP450 involvementPotential for liver toxicityGallstone formation

Interacting drugs

Statins

2 more in the full profile.

Biomarkers

7α-hydroxycholesterol levelsBile acid levels

Beyond the preview

Go deeper on Cholesterol 7 alpha-hydroxylase (None).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Cholesterol 7 alpha-hydroxylase (None).

Explore the full profile