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Target intelligence / Profile preview
Cholesterol 7 alpha-hydroxylase
- Molecular classification
- Enzyme, Cytochrome P450
01
Overview
Cholesterol 7 alpha-hydroxylase (CYP7A1) is a cytochrome P450 heme enzyme that catalyzes the first and rate-limiting step in the classic pathway of bile acid synthesis from cholesterol. It is essential for cholesterol catabolism, bile acid production, and overall cholesterol homeostasis. Mutations or dysregulation of CYP7A1 are associated with hyperlipidemia, gallstone disease, and resistance to statin therapy. It's also a potential therapeutic target for various metabolic and liver diseases.
02
Mechanism of action
Inhibition of CYP7A1 leads to reduced bile acid synthesis and increased cholesterol levels. Activation leads to increased bile acid synthesis.
03
Biological functions
Cholesterol catabolismBile acid synthesisRegulation of cholesterol homeostasis
04
Disease associations
HyperlipidemiaGallstone diseaseCardiovascular diseaseMetabolic diseaseNAFLD/NASHDiabetesObesityCirrhosisHepatocellular carcinoma
05
Safety considerations
Drug-drug interactions due to CYP450 involvementPotential for liver toxicityGallstone formation
06
Interacting drugs
Statins
2 more in the full profile.
07
Biomarkers
7α-hydroxycholesterol levelsBile acid levels
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