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Cholesterol Absorption
- Molecular classification
- Physiological Process
01
Overview
Cholesterol absorption refers to the process by which cholesterol from dietary sources and bile is taken up from the intestinal lumen into enterocytes (intestinal epithelial cells), processed, and then transported into circulation. This process is a critical determinant of whole-body cholesterol homeostasis and is a major target for lipid-lowering therapies. Key proteins involved include NPC1L1 (uptake), ABCG5/G8 (efflux), ACAT2 (esterification), and ABCA1 (HDL export).
02
Mechanism of action
Inhibition of NPC1L1-mediated cholesterol uptake; competition for micellar incorporation.
03
Biological functions
Dietary cholesterol uptakeBiliary cholesterol uptakeRegulation of plasma lipoprotein levelsCholesterol homeostasis
04
Disease associations
HypercholesterolemiaMetabolic diseases (e.g., diabetes mellitus, familial hypercholesterolemia)
05
Interacting drugs
Ezetimibe
2 more in the full profile.
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