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Cholesterol Binding

Molecular classification: Protein domain, Structural motif

Overview

Cholesterol binding refers to the molecular interaction between cholesterol and specific proteins or protein domains. This interaction is crucial for various biological processes, including membrane structure maintenance, regulation of membrane protein function, intracellular cholesterol transport, and allosteric modulation of receptors. Key structural motifs include CRAC and CARC. Examples include interactions with NPC1, ion channels (nAChR), viral proteins (Influenza M2), and GPCRs (β2AR).

Other names: Cholesterol interactionCRAC motifCARC motifCholesterol Recognition/interaction Amino acid Consensus

Biological functions

Membrane protein modulationMembrane integrityIntracellular cholesterol transportAllosteric regulation

Disease associations

Niemann-Pick Type C diseaseCardiovascular diseaseInfection (e.g., Influenza)

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