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Cholesterol Catabolism Pathway in Mycobacterium tuberculosis (Cholesterol Catabolism Pathway (Mtb))
- Target
- Cholesterol Catabolism Pathway (Mtb)
- Molecular classification
- Metabolic Pathway, Enzymatic Pathway
01
Overview
The cholesterol catabolism pathway in Mycobacterium tuberculosis (Mtb) is a crucial metabolic process that enables the bacterium to utilize host-derived cholesterol as a carbon and energy source during infection. This pathway is essential for Mtb’s survival, persistence, and virulence within the host, particularly inside macrophages. The pathway involves cholesterol uptake, side chain degradation, ring cleavage, and integration of catabolic products into central metabolic pathways. Key proteins involved include mce4 (cholesterol transporter), CYP125/CYP142/CYP124 (cytochrome P450s for side-chain oxidation), and KstR/KstR2 (transcriptional regulators). Targeting this pathway represents a potential therapeutic strategy for tuberculosis.
- Other names
- Cholesterol Degradation Pathway (Mtb)Sterol Metabolism in Mtb
02
Mechanism of action
Inhibition of cholesterol uptake, side chain oxidation, or ring cleavage, leading to disruption of bacterial energy production and survival.
03
Biological functions
Carbon Source UtilizationEnergy ProductionBacterial SurvivalIntracellular GrowthPersistenceVirulence
04
Disease associations
TuberculosisChronic InfectionGranuloma Formation
05
Safety considerations
Potential for off-target effects on host cholesterol metabolismDevelopment of drug resistance
06
Interacting drugs
Cytochrome P450 inhibitors (e.g., CYP125 inhibitors)
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