Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Cholesterol-Dependent Pathway in Mycobacterium tuberculosis
- Molecular classification
- Metabolic Pathway, Drug Metabolism, Steroid Metabolism
01
Overview
The cholesterol-dependent pathway in *Mycobacterium tuberculosis* (Mtb) refers to the bacterium’s ability to acquire, metabolize, and utilize host-derived cholesterol as a critical nutrient source during infection. This pathway is essential for Mtb survival, persistence within host macrophages, and pathogenesis. It involves cholesterol uptake via the Mce4 transporter and host receptors, catabolism via enzymes like cytochrome P450s and sterol-CoA ligase, and regulation by transcriptional factors like KstR and KstR2. Targeting this pathway offers potential therapeutic strategies by inhibiting bacterial acquisition/metabolism or reducing host cell cholesterol levels.
02
Mechanism of action
Inhibition of cholesterol uptake or catabolic enzymes.
03
Biological functions
Nutrient acquisitionEnergy productionBacterial survivalBacterial persistenceVirulenceLipid metabolism
04
Disease associations
TuberculosisInfectionGranuloma formation
05
Safety considerations
Potential for off-target effects on host cholesterol metabolismDevelopment of drug resistance
06
Interacting drugs
Azoles (targeting P450s)
Beyond the preview
Go deeper on Cholesterol-Dependent Pathway in Mycobacterium tuberculosis.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Cholesterol-Dependent Pathway in Mycobacterium tuberculosis.