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Target intelligence / Profile preview
Cholesterol efflux via HDL pathway (HDL pathway)
- Target
- HDL pathway
- Molecular classification
- Pathway, Lipid transport, Reverse Cholesterol Transport
01
Overview
Cholesterol efflux via the HDL pathway is a critical biological process in which excess cholesterol is transported from peripheral cells to high-density lipoprotein (HDL) particles. This process initiates reverse cholesterol transport (RCT), ultimately delivering cholesterol to the liver for excretion or recycling. The pathway plays a central role in maintaining cellular cholesterol homeostasis and protecting against atherosclerosis.
- Other names
- Reverse cholesterol transport (RCT)HDL-mediated cholesterol efflux
02
Mechanism of action
N/A
03
Biological functions
Cholesterol homeostasisLipid transportReverse cholesterol transportAtheroprotection
04
Disease associations
AtherosclerosisCardiovascular diseaseHyperlipidemia
05
Safety considerations
Potential for off-target effects on lipid metabolismVariability in patient response based on genetic background and lifestyle factors
06
Biomarkers
HDL-cholesterol levelsApoA-I levelsABCA1 expressionCholesterol efflux capacity
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