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Target intelligence / Profile preview
Cholesterol Gallstone Formation
- Molecular classification
- Metabolic disorder, Biliary disease
01
Overview
Cholesterol gallstone formation is a complex process involving cholesterol supersaturation in bile, crystal precipitation, gallbladder dysfunction, and mucin accumulation. It is influenced by hepatic, gallbladder, and intestinal factors, as well as genetic predisposition and various risk factors. The process can lead to several clinical manifestations including biliary colic, cholecystitis, choledocholithiasis and biliary pancreatitis.
- Other names
- GallstonesCholelithiasisBiliary calculiCholesterol stones
02
Mechanism of action
Ursodeoxycholic and chenodeoxycholic acid reduce cholesterol saturation in bile, facilitating gallstone dissolution. Statins and fibrates impact cholesterol metabolism.
03
Biological functions
Bile productionCholesterol metabolismGallbladder functionBile salt homeostasis
04
Disease associations
Biliary colicCholecystitisCholedocholithiasisBiliary pancreatitis
05
Safety considerations
Drug-induced liver injuryGallstone recurrenceComplications of cholecystectomy
06
Interacting drugs
Ursodeoxycholic acid
3 more in the full profile.
07
Biomarkers
Bile cholesterol saturation indexSerum cholesterol levelsLiver function testsGallbladder ultrasound
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