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Target intelligence / Profile preview
Cholesterol induced regulator of metabolism RNA (CHROMR)
- Target
- CHROMR
- Molecular classification
- Long non-coding RNA (lncRNA), Other
01
Overview
Cholesterol induced regulator of metabolism RNA (CHROMR, also known as CHROME or PRKRA-AS1) is a primate-specific long non-coding RNA located on human chromosome 2q31.2. CHROMR is upregulated in plasma and arterial plaques of patients with cardiovascular disease, and its expression is regulated by sterol-activated LXR transcription factors. Functionally, CHROMR promotes cholesterol efflux and HDL synthesis by inhibiting the activity of specific microRNAs (miR-27b, miR-33a/b, miR-128) that otherwise suppress ABCA1, an essential gene for HDL formation. Knockdown of CHROMR reduces cholesterol efflux and impairs nascent HDL biogenesis. CHROMR is being explored as a biomarker and experimental regulator for cholesterol-related diseases but is not a direct drug target, nor is it a receptor, enzyme, or transporter.
- Other names
- CHROMEcholesterol homeostasis regulator of miRNA expressionPRKRA-AS1PRKRA antisense RNA 1
02
Biological functions
Regulation of cholesterol homeostasisRegulation of microRNA activityCholesterol effluxRegulation of HDL synthesis
03
Disease associations
Cardiovascular diseaseAtherosclerosisLipid-related diseaseOther
04
Safety considerations
Limited pharmacological tractabilityTherapeutic targeting challenges due to poor conservation across species
05
Biomarkers
Plasma CHROME/CHROMR levels (for cholesterol-related diseases, e.g. cardiovascular disease)
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