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Target intelligence / Profile preview
Cholesterol Side Chain Cleavage Enzyme (CYP11A1)
- Target
- CYP11A1
- Molecular classification
- Enzyme, Cytochrome P450 monooxygenase
01
Overview
The cholesterol side-chain cleavage enzyme (CYP11A1), also known as P450scc, is a mitochondrial cytochrome P450 monooxygenase that catalyzes the conversion of cholesterol to pregnenolone. This is the first and rate-limiting step in steroidogenesis, leading to the biosynthesis of all steroid hormones. Deficiency or mutations in CYP11A1 cause congenital lipoid adrenal hyperplasia, characterized by adrenal insufficiency and impaired sexual development.
- Other names
- P450sccCholesterol Desmolase
02
Mechanism of action
Inhibition of cholesterol conversion to pregnenolone
03
Biological functions
Steroid hormone biosynthesisVitamin D metabolism
04
Disease associations
Congenital lipoid adrenal hyperplasiaAdrenal insufficiencyImpaired sexual development
05
Safety considerations
Adrenal insufficiencySex reversal in genetic malesUnderdeveloped genitalia
06
Interacting drugs
Ketoconazole
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