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Target intelligence / Profile preview
Choline Kinase (ChoK)
- Target
- ChoK
- Molecular classification
- Enzyme, Kinase
01
Overview
Choline kinase (CK, also known as ChoK) is a cytosolic enzyme that catalyzes the phosphorylation of choline to form phosphocholine in the presence of ATP and magnesium. This reaction is the first and committed step in the CDP-choline pathway for phosphatidylcholine (PC) biosynthesis, which is essential for membrane formation and cellular signaling. Overexpression or dysregulation of CK—especially ChoKα—is linked to malignant transformation across various cancers, making it a promising target for anticancer therapy. ChoKα has also been implicated as a potential therapeutic target for obesity.
- Other names
- CKCHKACHKBChoKαCHKα1CHKα2CHKβ
02
Mechanism of action
Small molecule inhibitors block catalytic site or disrupt dimerization, decreasing phosphocholine levels and impairing tumor cell proliferation.
03
Biological functions
PhosphorylationPhosphatidylcholine biosynthesisMembrane formationCell signalingCholesterol transportSecond messenger productionCell growth regulationCell division regulationSphingomyelin production
04
Disease associations
CancerObesity
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