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Target intelligence / Profile preview
Choline kinase alpha (CHKA)
- Target
- CHKA
- Molecular classification
- Enzyme
01
Overview
Choline kinase alpha (CHKA) is a cytosolic enzyme that catalyzes the phosphorylation of free choline to phosphocholine, the first and rate-limiting step in the CDP-choline pathway for phosphatidylcholine production. It plays an essential role in membrane biogenesis, lipid metabolism, signal transduction, and the regulation of cell growth and proliferation. CHKA is overexpressed in various cancers and is a target for small-molecule inhibitors under investigation as anticancer agents. It is also implicated in neurodevelopmental disorders.
- Other names
- CKIEKEthanolamine kinaseChk
02
Mechanism of action
Inhibition of choline kinase alpha activity
03
Biological functions
Lipid metabolismMembrane biogenesisSignal transductionRegulation of cell growthCell proliferation
04
Disease associations
CancerNeurodevelopmental disordersRheumatoid arthritisInflammatory diseasesInfection
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