CTP:phosphocholine cytidylyltransferase (CCT) (CCT)

CTP:phosphocholine cytidylyltransferase (CCT) is the rate-limiting enzyme in the CDP-choline pathway, also known as the Kennedy pathway, which is the primary route for the de novo synthesis of phosphatidylcholine (PC) in mammalian cells (UniProt P49585). As PC is the most abundant phospholipid in eukaryotic membranes, CCT is a critical regulator of membrane biogenesis, cell growth, and lipoprotein assembly (NCBI Gene PCYT1A). The enzyme}

Other names

Phosphocholine cytidylyltransferasePCYT1Choline-phosphate cytidylyltransferaseCTP:choline-phosphate cytidylyltransferaseCCT-alphaCCT-betaPCYT1APCYT1B

Inhibition of the rate-limiting step in the Kennedy pathway (CDP-choline pathway) for phosphatidylcholine synthesis, leading to membrane disruption, impaired cell signaling, and induction of apoptosis (PubMed PMID: 11063872).