Choline phosphotransferase 1 (CHPT1)

Choline phosphotransferase 1 (CHPT1) is an enzyme primarily localized in the Golgi apparatus that catalyzes the final step in the cytidine diphosphate-choline (CDP-choline) pathway, transferring phosphocholine from CDP-choline to diacylglycerol to generate phosphatidylcholine (PC)[2][3]. This process is a major pathway for de novo PC synthesis, critical for the formation and maintenance of cellular membranes. CHPT1 acts alongside choline/ethanolamine phosphotransferase 1 (CEPT1), but provides distinct subcellular pools of PC, and recent studies suggest only PC produced by CEPT1, not CHPT1, regulates feedback inhibition of nuclear CCTα or lipid droplet biogenesis[2]. Altered expression of CHPT1 has been linked to acquired drug resistance in prostate cancer, and pathogenic variants cause presynaptic congenital myasthenic syndrome[2][3]. CHPT1 is an established enzyme target in lipid metabolism, with growing research interest in its biological and pathological roles.

Other names

Choline phosphotransferase 1CHPT1CPT1hCPT1Diacylglycerol cholinephosphotransferase 1phosphatidylcholine synthesizing enzymeAAPT1-like protein