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Target intelligence / Profile preview
Choline Transporter (ChT)
- Target
- ChT
- Molecular classification
- Transporter, Membrane protein
01
Overview
The choline transporter is a membrane protein responsible for the uptake of choline into cells, particularly neurons that synthesize acetylcholine. There are several types of choline transporters, including the high-affinity choline transporter (CHT1/SLC5A7) primarily found in cholinergic neurons, choline transporter-like protein 1 (CTL1) which is an intermediate-affinity, Na+-independent transporter and choline transporter-like protein 2 (CTL2) which is a low-affinity transporter highly expressed on mitochondrial membranes. FLVCR2 is also identified as a primary brain choline importer at the blood-brain barrier. These transporters play crucial roles in maintaining adequate levels of acetylcholine, neurotransmission, and cellular metabolism. Inhibitors like Hemicholinium-3 (HC-3) can block choline transport, impairing acetylcholine synthesis.
- Other names
- High-affinity choline transporter (CHT1/SLC5A7)Choline transporter-like protein 1 (CTL1)Choline transporter-like protein 2 (CTL2)FLVCR2
02
Mechanism of action
Competitive inhibition of choline transport
03
Biological functions
Choline transportAcetylcholine synthesisNeurotransmissionMitochondrial choline uptake and excretionBetaine synthesisEpigenetic regulation
04
Disease associations
Neurological disordersCognitive dysfunction
05
Safety considerations
Disruption of neurotransmitter synthesisMetabolic imbalanceNeurological phenotypes
06
Interacting drugs
Hemicholinium-3 (HC-3)
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