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Choline Transporter Protein
- Molecular classification
- Transporter, Solute Carrier Family, Membrane protein
01
Overview
The choline transporter protein family encompasses several membrane transporters responsible for the uptake of choline, an essential nutrient. These include the high-affinity choline transporter 1 (CHT1/SLC5A7), choline transporter-like proteins (CTLs/SLC44 family), and polyspecific organic cation transporters (OCTs). CHT1 is crucial for acetylcholine synthesis in cholinergic neurons. CTLs play roles in both plasma membrane and mitochondrial choline transport. Dysfunction or inhibition of these transporters can impact neurotransmission and cell proliferation, making them relevant in neurodegenerative diseases and cancer.
- Other names
- CHT1SLC5A7CTL1CTL2CTL3CTL4CTL5SLC44A1SLC44A2SLC44A3SLC44A4SLC44A5OCT1OCT2Organic cation transporters
02
Mechanism of action
Inhibition of choline uptake
03
Biological functions
Choline transportAcetylcholine synthesisPhosphatidylcholine synthesisBetaine synthesisNeurotransmissionMembrane biosynthesisCell proliferation
04
Disease associations
Alzheimer's diseaseCancerNeurodegenerative disease
05
Safety considerations
Impaired neurotransmissionPotential impact on cell growth and proliferation
06
Interacting drugs
Hemicholinium-3
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