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Target intelligence / Profile preview
Choline trimethylamine-lyase (CutC)
- Target
- CutC
- Molecular classification
- Enzyme, Glycyl radical enzyme
01
Overview
Choline trimethylamine-lyase (CutC) is an anaerobic bacterial enzyme that catalyzes the cleavage of choline into trimethylamine (TMA) and acetaldehyde. This reaction is a key step in the microbial metabolism of choline within the human gut microbiota. The enzyme belongs to the glycyl radical enzyme (GRE) family and requires activation by a partner protein, CutD. TMA produced by this pathway is absorbed and converted in the liver to trimethylamine N-oxide (TMAO), which has been linked to increased risk of cardiovascular diseases and other metabolic disorders in humans. Inhibition of CutC is being explored as a therapeutic strategy.
- Other names
- CutC
02
Mechanism of action
Inhibition of choline trimethylamine-lyase activity
03
Biological functions
Choline metabolismTrimethylamine production
04
Disease associations
Cardiovascular diseaseMetabolic disorders
05
Safety considerations
Potential disruption of gut microbiota if inhibition is not specific
06
Interacting drugs
Fluoromethylcholine
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