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Target intelligence / Profile preview
Muscarinic Acetylcholine Receptor (mAChR)
- Target
- mAChR
- Molecular classification
- G protein-coupled receptor, GPCR, Receptor
01
Overview
Muscarinic acetylcholine receptors (mAChRs) are a family of G protein-coupled receptors that mediate the effects of the neurotransmitter acetylcholine in both the central and peripheral nervous systems. There are five subtypes (M1-M5), which differ in tissue distribution, signaling mechanisms, and physiological roles. They are major drug targets, with agonists used for conditions with reduced cholinergic activity and antagonists used to treat symptoms of cholinergic excess or block unwanted parasympathetic activity.
- Other names
- Muscarinic receptormACh receptorsCholinergic muscarinic receptor
02
Mechanism of action
Agonists or antagonists binding to mAChRs, modulating intracellular signaling cascades through G proteins, leading to changes in effector protein activity and downstream physiological effects.
03
Biological functions
Signal transductionParasympathetic nervous system regulationCentral nervous system modulationRegulation of smooth muscle contractionRegulation of cardiac muscle contractionRegulation of glandular secretionModulation of neurotransmitter releaseLearning and memoryRegulation of heart rateControl of sweat gland activity
04
Disease associations
Neurodegenerative diseaseCardiovascular diseaseGastrointestinal disordersCognitive disordersDementiaAlzheimer's disease
05
Safety considerations
Anticholinergic side effects (e.g., dry mouth, blurred vision, constipation, urinary retention)Cardiac effects (e.g., bradycardia or tachycardia)Central nervous system effects (e.g., confusion, hallucinations)
06
Interacting drugs
Acetylcholine
4 more in the full profile.
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