Target intelligence / Profile preview

Acetylcholine Receptor (AChR)

Target: AChR
Molecular classification: Receptor, Ligand-gated ion channel (Nicotinic), G protein-coupled receptor (Muscarinic)

Overview

The acetylcholine receptor (AChR), also known as a cholinergic receptor, is an integral membrane protein that responds to the neurotransmitter acetylcholine. These receptors are essential for transmitting signals across synapses in both the central and peripheral nervous systems, mediating muscle contraction, autonomic nervous system responses, and various brain functions including memory and learning.

Other names: Cholinergic receptor

Mechanism of action

Agonist or antagonist binding to acetylcholine receptors, modulating ion channel activity (nicotinic) or G-protein signaling (muscarinic).

Biological functions

Signal transductionNeuromuscular transmissionAutonomic nervous system signalingCognitive processes (memory and learning)

Disease associations

Myasthenia gravisNeurodegenerative diseaseCognitive disorders

Safety considerations

Side effects associated with cholinergic agonists (e.g., bradycardia, increased secretions)Side effects associated with cholinergic antagonists (e.g., dry mouth, blurred vision)

Interacting drugs

Acetylcholine

4 more in the full profile.

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