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Target intelligence / Profile preview
Cholinergic receptor muscarinic (mAChR)
- Target
- mAChR
- Molecular classification
- G protein-coupled receptor, GPCR, Receptor
01
Overview
Cholinergic receptor muscarinic (mAChR) is a type of acetylcholine receptor that is a G protein-coupled receptor. There are five subtypes, M1-M5, which are widely distributed in the central nervous system and peripheral tissues. They mediate parasympathetic nervous system responses and are involved in various physiological functions, including heart rate regulation, smooth muscle contraction, glandular secretion, and cognitive processes. Drugs targeting mAChRs are used to treat a variety of conditions, but their use is often limited by anticholinergic side effects.
- Other names
- Muscarinic acetylcholine receptormAChRsCHRM1CHRM2CHRM3CHRM4CHRM5
02
Mechanism of action
Agonists or antagonists of muscarinic acetylcholine receptors modulate downstream signaling pathways, including activation or inhibition of phospholipase C (PLC) and adenylate cyclase, affecting intracellular calcium levels and cAMP production.
03
Biological functions
Signal transductionParasympathetic nervous system regulationRegulation of heart rateSmooth muscle contractionGlandular secretionCognitive functionMotor controlRegulation of dopamine release
04
Disease associations
Alzheimer's diseaseParkinson's diseaseSchizophreniaCardiovascular diseaseGastrointestinal disordersOveractive bladderDry eye diseaseMotion sickness
05
Safety considerations
Anticholinergic side effects (e.g., dry mouth, blurred vision, constipation, urinary retention)Cognitive impairmentTachycardiaAngle-closure glaucomaDrug interactions
06
Interacting drugs
Atropine
5 more in the full profile.
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