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Target intelligence / Profile preview
Cholinergic receptor muscarinic M1 (CHRM1)
- Target
- CHRM1
- Molecular classification
- G protein-coupled receptor, Receptor
01
Overview
The cholinergic receptor muscarinic M1 (CHRM1) is a G protein-coupled receptor that binds acetylcholine. It is predominantly expressed in the central nervous system, exocrine glands, and gastric tissue. It plays a crucial role in cognitive processes such as learning and memory, neuronal excitability, and glandular secretion. Dysregulation of M1 receptor signaling has been implicated in cognitive disorders and autoimmune conditions. Antagonists can cause side effects such as dry mouth and confusion.
- Other names
- Muscarinic acetylcholine receptor M1M1 receptor
02
Mechanism of action
Agonism or antagonism of M1 receptor, modulating downstream signaling pathways such as PLC/IP3/DAG and calcium mobilization
03
Biological functions
Signal transductionNeurotransmission modulationNeuronal excitability enhancementSynaptic plasticity modulationSecretion regulation
04
Disease associations
Cognitive disordersAutoimmune conditionsAnxiety
05
Safety considerations
Dry mouthConfusionDelirium-like statesHallucinationsVagally-induced bronchoconstriction
06
Interacting drugs
Acetylcholine
3 more in the full profile.
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