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Target intelligence / Profile preview
Cholinergic Receptor Muscarinic Type 3 (M3)
- Target
- M3
- Molecular classification
- G protein-coupled receptor, GPCR, Receptor
01
Overview
The cholinergic receptor muscarinic type 3 (M3) is a G protein-coupled receptor that mediates smooth muscle contraction, glandular secretion, and insulin release. It is widely distributed throughout the body and plays a crucial role in parasympathetic nervous system function. As a therapeutic target, it is primarily addressed in airway diseases like COPD and asthma with drugs like tiotropium.
- Other names
- CHRM3
02
Mechanism of action
Antagonism of M3 receptors leading to smooth muscle relaxation and reduced secretions.
03
Biological functions
Signal transductionSmooth muscle contractionGlandular secretionInsulin secretionVasodilation (endothelium-dependent)Vasoconstriction (endothelium-independent)Emesis control
04
Disease associations
COPDAsthma
05
Safety considerations
Non-selective muscarinic antagonists can cause a range of side effects due to the widespread distribution of muscarinic receptors.Side effects can include dry mouth, blurred vision, constipation, and urinary retention.
06
Interacting drugs
Acetylcholine
1 more in the full profile.
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