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Target intelligence / Profile preview
Cholinergic Signaling Pathway (N/A)
- Target
- N/A
- Molecular classification
- Signaling pathway
01
Overview
The cholinergic signaling pathway is a network of molecular and cellular mechanisms mediated by acetylcholine (ACh), a key neurotransmitter involved in neuronal excitability, synaptic transmission, muscle contraction, autonomic functions, and immune responses. It involves ACh synthesis, release, receptor binding (muscarinic and nicotinic receptors), and degradation by acetylcholinesterase. Dysregulation of this pathway is implicated in various diseases, making it a target for therapeutic interventions.
- Other names
- Acetylcholine pathwayCholinergic systemACh signaling
02
Mechanism of action
Modulation of acetylcholine levels or receptor activity
03
Biological functions
NeurotransmissionMuscle contractionAutonomic regulationCognitionMemoryImmune response
04
Disease associations
Alzheimer's diseaseMyasthenia gravisGlaucomaEpilepsySepsisDementia
05
Safety considerations
Side effects of cholinesterase inhibitors (e.g., nausea, vomiting)Cardiovascular effects of muscarinic agonistsNeuromuscular effects of nicotinic agonists
06
Interacting drugs
Cholinesterase inhibitors
4 more in the full profile.
07
Biomarkers
Acetylcholine levels in cerebrospinal fluidExpression levels of cholinergic receptorsActivity of acetylcholinesterase
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