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Chondroadherin-like protein (CHADL)
- Target
- CHADL
- Molecular classification
- Small leucine-rich repeat protein (SLRP), Proteoglycan, Extracellular matrix protein, Other
01
Overview
Chondroadherin-like protein (CHADL) is a small leucine-rich repeat proteoglycan (SLRP) located in the extracellular matrix, primarily in cartilaginous tissues. CHADL binds collagen and regulates the organization of collagen fibrils, playing a negative regulatory role in collagen fibrillogenesis. It modulates chondrocyte (cartilage cell) differentiation — knockdown of the gene accelerates cartilage formation and matrix deposition. CHADL's molecular profile and functions are similar to other SLRP family proteins, but it is distinguished by its tissue-specific role in cartilage and potential as a biomarker for early tissue degeneration and biomechanical alteration. There is currently no evidence that CHADL functions as a direct therapeutic target for drugs, nor is it categorized as a receptor, enzyme, transporter, or transcription factor.
- Other names
- CHADLChondroadherin-like proteinSLRR4B
02
Biological functions
Negative regulation of collagen fibril organizationCollagen bindingCollagen fibril bindingModulation of chondrocyte differentiationExtracellular matrix organization
03
Disease associations
Connective tissue and cartilage pathologyPotential in osteoarticular degenerative diseasesHypotrichosis 3Other
04
Biomarkers
Emerging marker for tissue degeneration and changes in biomechanical homeostasis, especially in cartilage and intervertebral disc pathology
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