Target intelligence / Profile preview

Chondroitin 4-sulfate (C4S)

Target
C4S
Molecular classification
Glycosaminoglycan, Sulfated polysaccharide
01

Overview

Chondroitin 4-sulfate, also known as chondroitin sulfate A, is a sulfated glycosaminoglycan (GAG) and a derivative of chondroitin in which the sulfate group is esterified to carbon 4 of the N-acetylgalactosamine (GalNAc) sugar. It is a linear heteropolysaccharide composed of repeating disaccharide units—glucuronic acid and galactosamine—commonly found covalently linked to proteins as part of proteoglycans in connective tissues such as cartilage. While used as a dietary supplement for osteoarthritis, large clinical trials have not demonstrated significant symptomatic benefit.

Other names
Chondroitin sulfate AChondroitin A sulfateChondroitin 4-(hydrogen sulfate)CHEBI:18250
02

Mechanism of action

N/A

03

Biological functions

Structural component of cartilageComponent of proteoglycan complexesWater retention in tissues
04

Disease associations

OsteoarthritisCardiovascular disease (potential role)
05

Interacting drugs

Glucosamine

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