Target intelligence / Profile preview

Chondroitin sulfate proteoglycan 4 pseudogene 12 (CSPG4P12)

Target: CSPG4P12
Molecular classification: Other (Pseudogene, long non-coding RNA)

Overview

Chondroitin sulfate proteoglycan 4 pseudogene 12 (CSPG4P12) is a pseudogene-derived long non-coding RNA closely homologous to the protein-coding CSPG4 gene. Unlike classic druggable protein targets, CSPG4P12 is not a receptor, enzyme, or transporter, but a non-protein-coding pseudogene transcript. It is implicated in tumor suppression, as overexpression of CSPG4P12 inhibits cell proliferation, migration, invasion, and adhesion in non-small cell lung cancer and colorectal cancer cell models, while promoting apoptosis potentially via the p53/Bcl2/Bax mitochondrial apoptotic pathway and modulating epithelial-mesenchymal transition (EMT) markers. CSPG4P12’s reduced expression has been observed in tumor tissues compared to adjacent normal tissues, suggesting it may act as a transcriptional regulator or competing endogenous RNA in cancer biology.

Other names: CSPG4P9chondroitin sulfate proteoglycan 4 pseudogene 9CSPG4P12

Biological functions

Regulation of gene expressionModulation of cell proliferationInhibition of cell migrationInhibition of cell invasionPromotion of apoptosis

Disease associations

Cancer (notably non-small cell lung cancer, colorectal cancer)

Biomarkers

Lower expression in certain cancers (e.g. non-small cell lung cancer, colorectal cancer)

Beyond the preview

Go deeper on Chondroitin sulfate proteoglycan 4 pseudogene 12 (CSPG4P12).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Chondroitin sulfate proteoglycan 4 pseudogene 12 (CSPG4P12).

Explore the full profile